bcl-2 gene expression in hematopoietic cell differentiation

bcl-2 gene expression in hematopoietic cell differentiation.

Nonrandom translocations with breakpoint at band q21 on chromosome 18 might cause bcl-2 gene deregulation and might contribute to neoplastic transformation in human lymphomas. As the pattern of expression of bcl-2 in hematopoietic cells is still unclear, we have measured the level of the corresponding messenger RNA (mRNA) in a variety of myeloid and lymphoid cell malignancies not usually associ...

Comparison of BAX and Bcl-2 Expression During Human Embryonic Stem Cell Differentiation into Cardiomyocytes and Doxorubicin-induced Apoptosis

Back ground: Although the cell differentiation is an inseparable part of development in multicellular organisms, the regulating molecular pathway of it still is not fully defined. In the other hand, apoptosis is a fundamental physiological process which plays an essential role in a variety of biological events during development. Moreover, recent studies have found that apoptosis shows several ...

Key Regulatory Gene Expression in Erythroleukemia Differentiation

The characteristics of cellular and molecular mechanisms associated with cell proliferation and differentiation is important to understand malignancy. In this report we characterise a leukemic model, D5A1, to study the action of differentiation agent, cellular events and gene expression of the selected transcription factors. Cells induced with 4 mM hexamethylene bisacetamide (HMBA) caused signs...

Expression in Hematopoietic Progenitor E2F4 Modulates Differentiation and Gene

Gene expression profiling for hematopoietic cell culture

The sequencing of the genome of several organisms combined with the development of microarray technology has, for the first time, allowed investigators large-scale insight into the processes that are taking place inside cells at the molecular level. This form of analysis is useful from a bioprocess perspective at two levels. Firstly, the state of a cultured cell can be monitored in order to det...